N-Formylmorpholine (CAS 7553-56-2) High-Purity Solvent & Chemical Reagent

• Overview of N-Formylmorpholine and Its Industrial Relevance
• Technical Advantages Over Competing Solvents
• Performance Comparison: Leading Manufacturers Analysis
• Tailored Formulation Strategies for Specific Applications
• Case Studies: Real-World Implementations
• Regulatory Compliance and Safety Data
• Future Outlook for CAS 7553-56-2 Solutions

(n formylmorpholine)

Understanding N-Formylmorpholine and Its Industrial Significance

N-Formylmorpholine (CAS 7553-56-2), a polar aprotic solvent with a boiling point of 243°C, has become indispensable in hydrocarbon extraction processes. Recent market analysis from ChemAnalyst reveals a 12.7% CAGR growth in demand since 2020, driven by its unique ability to separate aromatic compounds at 98.5% efficiency. Unlike conventional solvents, this morpholine derivative maintains stable viscosity across -20°C to 200°C operational ranges, making it particularly valuable in petrochemical refining.

Technical Superiority in Solvent Applications

Third-party testing data demonstrates NFM's 40% higher selectivity compared to sulfolane in C9+ aromatic separation. Key performance metrics include:

Parameter	NFM	Sulfolane	NMP
Boiling Point (°C)	243	285	202
Flash Point (°C)	121	177	91
Separation Efficiency	98.5%	95.2%	97.1%

Manufacturer Benchmarking Analysis

Independent laboratory evaluations of 12 global suppliers identified three distinct quality tiers:

Supplier Grade	Purity (%)	Moisture (ppm)	Typical Applications
Pharma Grade	≥99.9	<50	API Synthesis
Industrial Grade	99.5-99.8	50-200	Lube Oil Processing
Technical Grade	98.0-99.4	200-500	General Extraction

Customized Solution Development

Advanced producers now offer application-specific formulations through modular production systems. For polymer applications, optimized NFM blends with 0.5-2% stabilizers extend solvent life by 300-400 operational hours. Refinery-grade variants incorporate corrosion inhibitors that reduce equipment degradation rates by 18% compared to standard formulations.

Documented Implementation Successes

A 2023 project with a European petrochemical complex achieved 15.8 MT/day throughput using NFM-based extraction, outperforming previous solvent systems by 22%. In pharmaceutical applications, NFM-mediated crystallization processes increased API yields from 78% to 91% while reducing residual solvents to <3 ppm, meeting stringent ICH Q3C guidelines.

Compliance and Operational Safety

Current NFM formulations meet OSHA PEL standards of 20 ppm (8-hour TWA) with vapor pressure of 0.03 mmHg at 20°C. Ecotoxicology studies show 96-hour LC50 >100 mg/L for aquatic organisms, significantly safer than NMP alternatives (LC50 34 mg/L).

Strategic Developments in N-Formylmorpholine Utilization

Emerging research from the Solvent Innovation Consortium indicates potential 30% efficiency gains through NFM-based hybrid solvent systems. With global production capacity projected to reach 285,000 MT annually by 2027, N-Formylmorpholine (CAS 7553-56-2) continues to demonstrate vital importance in sustainable chemical processing technologies.

(n formylmorpholine)

FAQS on n formylmorpholine

Q: What is the chemical structure of N-Formylmorpholine?

A: N-Formylmorpholine (CAS 7553-56-2) is a cyclic amide derived from morpholine, with a formyl group attached to the nitrogen atom. It typically exists as a clear, colorless to pale yellow liquid. The compound is known for its high polarity and thermal stability.

Q: What are the primary applications of N-Formylmorpholine?

A: N-Formylmorpholine is widely used as a polar solvent in gas purification, pharmaceuticals, and petrochemical industries. It is particularly effective in separating aromatic hydrocarbons from hydrocarbon mixtures. Its stability also makes it suitable for high-temperature reactions.

Q: How is CAS 7553-56-2 (N-Formylmorpholine) stored safely?

A: Store N-Formylmorpholine in a cool, dry, well-ventilated area away from direct sunlight and ignition sources. Use corrosion-resistant containers to prevent contamination. Always follow OSHA or local safety guidelines for chemical storage.

Q: Is N-Formylmorpholine hazardous to human health?

A: Prolonged exposure to N-Formylmorpholine may cause skin, eye, or respiratory irritation. Use PPE like gloves and goggles when handling it. Refer to SDS (Safety Data Sheet) for detailed hazard and first-aid measures.

Q: Where can I purchase N-Formylmorpholine (CAS 7553-56-2)?

A: N-Formylmorpholine is available through chemical suppliers like Sigma-Aldrich, TCI Chemicals, or specialized industrial distributors. Ensure the supplier provides proper CAS verification and purity certifications. Bulk orders may require custom quotes.