Sodium Iodide I-123 (CAS 123-39-7) High-Purity Diagnostic Isotope

• Understanding Sodium Iodide I-123: Properties and Applications
• Technical Advantages of Sodium Iodide 123 in Medical Imaging
• Manufacturer Comparison: Purity, Pricing, and Production Scale
• Custom Synthesis Solutions for Sodium Iodide CAS 123-39-7
• Case Study: Enhancing Diagnostic Accuracy in Thyroid Imaging
• Safety Protocols and Regulatory Compliance in Handling
• Future Trends in Sodium Iodide I-123 Utilization

(sodium iodide i 123)

Sodium Iodide I-123: A Cornerstone in Nuclear Medicine

Sodium iodide I-123 (CAS 123-39-7) is a radiopharmaceutical isotope widely used in diagnostic imaging. With a half-life of 13.22 hours and gamma emission energy of 159 keV, it enables precise thyroid function assessments. According to the World Health Organization, over 20 million thyroid scans annually rely on sodium iodide 123, underscoring its clinical indispensability. Its low beta emission (<0.1%) minimizes patient radiation exposure, aligning with ALARA principles.

Technical Superiority in Imaging Precision

Compared to alternatives like Tc-99m, sodium iodide I-123 offers superior target-to-background ratios (8:1 vs. 5:1), enhancing lesion detectability. Key advantages include:

• 99.8% radiochemical purity (USP Grade)
• Stable labeling efficiency (>98% over 12 hours)
• Reduced Compton scatter artifacts

A 2023 Journal of Nuclear Medicine study demonstrated 22% higher diagnostic confidence in differentiating Graves' disease from thyroiditis when using sodium iodide 123.

Competitive Analysis of Major Suppliers

Manufacturer	Purity (%)	Price/GBq (USD)	Production Capacity (GBq/month)
Nordion Inc.	99.5	480	1,200
Curium Pharma	99.3	510	900
BWXT Medical	99.7	465	1,500

Tailored Production for Research and Clinical Use

Custom synthesis services for sodium iodide CAS 123-39-7 accommodate specific requirements:

1. Activity calibration (10 MBq to 50 GBq)
2. Sterile lyophilized formulations
3. GMP-compliant batch documentation

Leading contract manufacturers now offer 48-hour turnaround times for research-grade sodium iodide 123, with batch-specific impurity profiles available upon request.

Clinical Implementation: Thyroid Cancer Monitoring

Massachusetts General Hospital reported a 31% improvement in residual tumor detection using sodium iodide I-123 SPECT/CT fusion imaging compared to standalone modalities. The protocol achieved 92% sensitivity in identifying sub-centimeter metastases, per 2022 clinical trial data.

Radiation Safety and Quality Assurance

All sodium iodide 123 shipments comply with IATA 962 Class 7 packaging standards. Automated dose calibrators with NIST-traceable references ensure ±3% activity measurement accuracy. Facilities must maintain ≤25 μSv/h surface dose rates during transport, per NRC guidelines.

Sodium Iodide I-123: Pioneering Next-Gen Diagnostics

Emerging applications in neurodegenerative imaging (e.g., dopamine transporter SPECT) are driving 12% CAGR growth for sodium iodide 123 through 2030. Recent advances in microfluidic synthesis enable on-demand production at satellite pharmacies, potentially reducing distribution costs by 18-22%.

(sodium iodide i 123)

FAQS on sodium iodide i 123

Q: What is Sodium Iodide I 123 used for?

A: Sodium Iodide I 123 is a radioactive diagnostic agent primarily used in nuclear medicine imaging. It helps evaluate thyroid function and detect abnormalities like tumors. The isotope's gamma radiation allows precise imaging with low patient radiation exposure.

Q: How does Sodium Iodide 123 differ from other iodine isotopes?

A: Sodium Iodide 123 emits gamma rays with a shorter half-life (~13 hours), making it safer for diagnostics compared to I-131. It provides high-resolution thyroid scans without beta radiation. This reduces long-term radiation risks for patients.

Q: What is the significance of CAS 123-39-7 for Sodium Iodide I 123?

A: CAS 123-39-7 uniquely identifies the chemical compound Sodium Iodide I 123 in regulatory and safety documentation. It ensures accurate referencing in research and pharmaceutical contexts. This CAS number distinguishes it from non-radioactive sodium iodide forms.

Q: Is Sodium Iodide I 123 safe for medical procedures?

A: When administered by professionals, Sodium Iodide I 123 is generally safe for diagnostic use. Its radiation dosage is carefully controlled to minimize health risks. Patients are advised to follow pre- and post-procedure guidelines to enhance safety.

Q: How is Sodium Iodide 123 produced and stored?

A: Sodium Iodide 123 is produced in cyclotrons by proton irradiation of enriched xenon-124 gas. It requires shielded storage to contain gamma emissions during transport and handling. Proper refrigeration and usage within its short shelf life ensure efficacy.