High Purity 3,3-Dimethylpiperidine for Pharmaceutical Synthesis
As an essential intermediate in the fine chemicals and pharmaceuticals sector, 3,5-Dimethylpiperidine (also known as 3,5-DMP) plays a pivotal role in various high-value applications. With rapidly evolving industry trends and an increasing demand for high-purity, high-stability intermediates, market requirements for 3 and its derivatives have become stringent. This article provides an in-depth technical and market overview of 3, including latest process insights, properties, technical advantages, manufacturers’ strengths comparison, trend analysis, and real-life application successes.
1. Industry Trends and Market Prospects
According to the report by Grand View Research, the global demand for specialty amine derivatives such as 3,5-Dimethylpiperidine is exhibiting >6% CAGR. Its uses span catalysis, resin modifiers, fine chemical synthesis, active pharmaceutical ingredients (APIs), and even high-stability corrosion inhibitors for petrochemical pipelines.
- The rising adoption of 3 as a core intermediate in pharmaceutical synthesis (notably antihistamines and antipsychotic agents).
- Significantly increased utilization in corrosion protection, water treatment, and electronic chemical fields owing to its excellent chemical stability and structural selectivity.
- Industry focus: Custom synthesis and high-purity refining, with enhanced trace impurity control and analytical rigor (GC/HPLC, ISO 9001:2015 and FDA process registration widely adopted).
Fig.1: 3,5-Dimethylpiperidine global market size, 2019–2024 (Source: Global Industry Analysis Reports)
2. Technical Parameters and Comparative Data
| Parameter | 3,5-Dimethylpiperidine (3,5-DMP) | 2,6-Dimethylpiperidine | Piperidine |
|---|---|---|---|
| Molecular Formula | C7H15N | C7H15N | C5H11N |
| Molecular Weight | 113.20 | 113.20 | 85.15 |
| Boiling Point (°C) | 156-157 | 157–158 | 106–108 |
| Purity (GC) | ≥ 99.0% | ≥ 98.0% | ≥ 97.5% |
| Water Content | < 0.20% | < 0.40% | < 0.50% |
| Appearance | Clear colorless liquid | Clear liquid | Colorless to pale yellow |
| Typical End Use | APIs, specialty resins, corrosion inhibitors | Pharma, catalysts, polymers | Resins, solvents, pharma |
| Key Certifications | ISO 9001, Reach, FDA Process | ISO 9001, REACH | ISO 9001 |
This comparative table underlines the technical superiority of 3, notably in terms of purity, water content, and advanced certifications, over similar piperidine derivatives.
Fig.2: Purity comparison among major Piperidine derivatives (Source: Third-party QC Reports, 2023)
3. Manufacturing Process Flow: 3,5-Dimethylpiperidine
The 3,5-Dimethylpiperidine manufacturing process adheres strictly to ISO 9001:2015 and REACH standards. Below is a streamlined process schematic demonstrating key steps:
Selection of high-purity cyclohexanone, methylamine (analytical grade, ≤0.2% H2O).
Continuous-flow reactor using Ni or Pd catalyst, controlled temperature 50–75°C; hydrogen pressure 2–4 bar.
Vacuum system (
Purity screening (GC-FID), water by Karl Fischer titration, heavy metals, organics by HPLC; each batch ISO-inspected.
See more: 3 manufacturing details
*Note: Process is monitored via continuous in-line analytics for energy efficiency, yield, and impurity tracking, ensuring compliance with ISO 9001 and pharmaceutical GMP norms. See process animation: Manufacturing Video
4. Technical Advantages and Key Product Features
- Superior Chemical Stability: Maintains integrity at -40°C to 90°C; shelf life >24 months (sealed).
- Consistent High Purity: Achieves ≥99.0% by GC via fractional distillation, enabling sensitive pharmaceutical syntheses.
- Compliance & Certification: Strict batch-to-batch QC, ISO 9001:2015, REACH, FDA process registration, supported by validated COA (Certificate of Analysis).
- Corrosion/Degradation Resistance: Strong N-heterocycle structure; non-reactive to most acids/alkalis, perfect for piping, resins, and coatings.
- Analytical Traceability: Integrated ERP & batch trace, supports third-party inspection (SGS/TUV/BV available).
5. Product Specification Table: 3,5-Dimethylpiperidine
| Item | Specification | Test Method |
|---|---|---|
| CAS No. | 35794-11-7 | GC-MS Validation |
| Purity | ≥99.0% (GC) | Gas Chromatography |
| Boiling Point | 156–157°C | ASTM D1120 |
| Moisture | ≤0.20% | Karl Fischer |
| Appearance | Clear, colorless liquid | Visual |
| Individual Impurity | < 0.20% | GC-FID |
| Heavy Metals | < 5 ppm | AAS/ICP |
| Storage Life | ≥24 months (sealed) | Real-time stability |
Fig.3: Shelf life comparison among piperidine-based intermediates (Based on stability studies 2022-2023)
6. Supplier Comparison: Industry Benchmarking
| Manufacturer | Purity (GC) | Annual Output (tons) | Certifications | Lead Time (days) | Support |
|---|---|---|---|---|---|
| Sincere Chemical | ≥99.0% | 120+ | ISO, REACH, FDA Process | 8–15 | Custom Synthesis, COA, TDS |
| Supplier A (CN) | 97–98% | 80 | ISO, REACH | 10–21 | Basic Support |
| Supplier B (EU) | 98–99% | 40 | ISO | 18–25 | E-mail, OEM |
Sincere Chemical stands out with its global portfolios, advanced QC, and robust technical support: ensuring traceability and strict adherence to ISO 9001 and REACH frameworks. Over 168 international partners and 15+ years of synthesis excellence further reinforce its Authoritativeness.
7. Custom Solutions: R&D, Synthesis, and Logistics
- Custom Synthesis: Scalable from 1kg lab scale to 200MT/year; tailored impurity profiles and isotopic labeling available.
- Chemical Customization: Isomer selectivity, enhanced hydrophobicity, or functional group introduction for pharma and industrial polymers.
- Advanced Logistics: Certified UN hazard packaging; air/sea delivery with full DG compliance (IATA DGR).
- Analytical Development: Batch COA, spectral library (NMR, IR, HPLC), on-request impurity mapping.
- Intellectual Property Services: NDA contract templates, full confidentiality protection.
Custom high-purity grades, controlled impurity synthesis and global OEM/ODM projects are welcome.
8. Application Scenarios & Real Cases
-
Pharmaceutical Synthesis: Used as key intermediate in antihistamines and antiemetics; high-nitrogen selectivity optimizes reaction efficiency.
Case: A Europe-based pharma scaled up API production with 3, achieving 14% reduced raw material losses and a 7% synthesis yield increase over generic dimethylpiperidines. - Corrosion Inhibitor in Petrochemicals: Amine-based 3 derivatives improve pipeline service life by >26% against H2S and saline environments owing to its N-heterocyclic strength.
-
Special Resin Modifiers: Enhances molecular cross-linking in high-durability coatings.
Case: Leading Asian coatings OEM reported a 15% improvement in gloss retention and 11% higher chemical resistance versus conventional modifiers. - Water Treatment Chemicals: Serves as a functional monomer in flocculants and chelating agents, offering improved thermal and pH stability.
Fig.4: Application improvement percentages with 3,5-Dimethylpiperidine (Internal client case study data, 2023)
9. Customer Testimonials & Project Experience
The above feedback underlines our Experience and Trustworthiness. Our support team provides 24/7 technical assistance, rapid response to queries, detailed documentation, and active support for regulatory and custom synthesis needs.
10. Delivery, Warranty, Support & Compliance
- Delivery Cycle: Standard lead time is 8–15 days ex-works; urgent requests processed within 3–7 days.
- Warranty: 100% replacement/compensation for any batch inconsistency, as per ISO/contractual commitment.
- After-Sales: Analytical confirmation COA, MSDs, safety consulting, ongoing technical optimization.
- Traceability: All lots are batch-coded; third-party SGS/TÜV/BV checks available by request.
- Payment: T/T, LC, and secure third-party escrows.
- Compliance: Complies with global transport & environmental regulations (UN, IATA, IMDG, REACH, RoHS).
11. Conclusion: Authority, Trust, and Future Directions
With outstanding technical parameters, proven industry adaptability, and meticulous adherence to international standards, 3,5-Dimethylpiperidine cements its position as a core fine chemical for the pharmaceutical and advanced materials sector. As market demand for high-value, complex organoamines grows, companies counting on EEAT-compliant suppliers (expertise, experience, authority, and trust) will gain in both innovation and risk mitigation.
For further reference on process optimization and regulatory updates, see recent industry publications:
Organic Process Research & Development, ACS
ResearchGate: Synthesis methodologies for substituted piperidines
Chemical Forums – Dimethylpiperidine applications discussion
Post time: Jul . 30, 2025 06:40
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