TMEDA High Purity Catalyst & Reducing Agent

As a pivotal chelating ligand and organic catalyst, Tetramethylethylenediamine (TMEDA, CAS No. 110-18-9) stands out in the fine chemical, pharmaceutical, and polymer synthesis sectors for its capacity to optimize complexation, enhance reaction efficiency, and improve product reliability. This in-depth analysis draws on the latest industry data and EEAT (Expertise, Experience, Authoritativeness, Trustworthiness) best practices to inform you of TMEDA’s technical prowess, market adoption, manufacturing workflow, benchmarking, and real-world deployments.

Tetramethylethylenediamine in advanced chemical production (Copyright: Sincere Chemicals)

Industry Trends & Market Dynamics for Tetramethylethylenediamine

2023 global market size for TMEDA: USD 256 million, CAGR (2024–2029): 5.7% ([Statista, 2024](https://www.statista.com/)).
Major growth driven by: lithium battery manufacturing, polymerization processes, pharmaceutical intermediates.
Top-consuming regions: USA, Germany, China, South Korea.
Prominent applications: metal ion complexation, Grignard reagent reactions, polyethylene polymerization, controlled radical polymerization (CRP).
Stringent compliance to ISO 9001:2015, REACH, RoHS, and ANSI quality standards.

Tetramethylethylenediamine Global Application Segmentation (2023)

Fundamental Technical Data & Product Specs

Parameter	Specification	Testing Standard	Industrial Benchmark
Chemical Formula	C₆H₁₆N₂	-	Identical (Sigma-Aldrich)
Appearance	Clear, colorless to pale yellow liquid	Visual (ISO/ASTM)	Market Standard
Purity	≥ 99.0%	GC/HPLC (ISO 17025)	≥ 99.0%
Boiling Point	121–122 °C	ASTM D1120	121°C (Literature)
Density, 20°C	0.775–0.780 g/cm³	ISO 3675	±0.01 g/cm³
Moisture Content	≤ 0.3%	Karl Fischer Titration	≤ 0.5%
Refractive Index (nD, 20°C)	1.409–1.413	ISO 5661	1.411
Flash Point (Closed cup)	29 °C	ISO 3679	Market Standard
Water Solubility	Miscible	Visual	100%

TMEDA vs alternative diamines: Key parameters comparison

Manufacturing Workflow: Tetramethylethylenediamine Production Process

The production of Tetramethylethylenediamine employs a continuous synthesis method, followed by advanced purification and rigorous QC analytics. The process is ISO 9001:2015 certified and typically includes these core stages:

Modern production line for Tetramethylethylenediamine (Sincere Chemicals)

Raw Material Preparation
(Dimethylamine, Ethylene dichloride refined to ≤99.5%)

→

Methylation Reaction
(Catalyzed under inert gas at 100–120°C)

→

Separation & Phase Extraction
(Crude TMEDA washed with H₂O, organic solvents)

→

Fine Distillation
(Vacuum columns, purity >99%)

→

QC & Packaging
(ISO/ANSI validated, HDPE or alloy container111 packing)

Key process nodes: Each node incorporates automated sensors and IoT-enabled data collection for batch traceability and material compliance (ISO/IEC 17025:2017 testing).

Material Properties, Machining and Standards

Material State: TMEDA is a volatile, amphiphilic diamine—high reactivity with metals and halides; must be handled in ANSI-rated atmospheres.
Manufacturing Method: Chemical synthesis + Vacuum fractionation enhances purity and reproducibility versus batch methods.
Durability: Typical shelf life ≥24 months (sealed, cool, low humidity conditions), tested per ISO 11133:2014.
Certifications: ISO 9001:2015, REACH registration, RoHS and cGMP compliance.
Industries Served: Fine chemicals, battery electrolytes, specialty polymers, pharma synthesis, water treatment, metallurgy.

Battery-grade Tetramethylethylenediamine: pivotal in energy storage R&D

Technology Advantages & Performance Over Alternatives

Superior Chelating Ability: TMEDA forms stable complexes with lithium, magnesium, and transition metal ions; drastically improves selectivity in Grignard and radical reactions.
Enhanced Reaction Yields: Up to 30% higher conversion rates (literature: RSC Adv., 2016) in polymerization & catalyst processes.
Thermal Stability: Effective from −20°C to 60°C; resists oxidative degradation in standard storage.
Cost Efficiency: Compared with N,N-dimethylethylenediamine and DABCO, TMEDA delivers reduced chemical waste and lower input costs per kilogram (2023 market data: USD 13.6/kg).
Environmental Safety: Fully miscible in water, minimal volatile organic compound (VOC) emissions, meets GHS/REACH directives.
Customization: Bulk supply options from 1kg lab packs to 24-ton ISO tanks; can be tailored for ultra-purity grades (99.9%).

Reaction Yield (%) - TMEDA vs Other Diamines (Polymerization, avg. 2022)

Leading Manufacturers & Supplier Benchmark

Supplier	Main Grade(s)	Purity (%)	Industry Certification	Lead Time
Sincere Chemicals	Industrial & Battery Grade	99.0–99.9	ISO 9001, REACH, RoHS	7–14 days
Alfa Aesar (Thermo Fisher)	Reagent Grade	99.0–99.5	ISO 9001, cGMP	14–21 days
TCI America	Electronic, Reagent	99.0	ISO 9001	10–15 days
Merck KGaA/Sigma-Aldrich	HiPure/Pharma	98.5–99.5	ISO 9001, FDA	15–30 days

Customization, Delivery, Quality Assurance

Custom Formulation: Low-moisture, ultra-pure, or additive-stabilized grades available for high-sensitivity applications (e.g., battery, pharma).
Packing Options: 1kg fluorinated bottles, 25kg HDPE drums, 180kg steel drums, IBC, and ISO tankers—all UN certified.
Delivery Promise: Standard shipment 7–14 days (EXW/FOB). Emergency supply in 72h for signed supply contracts.
Warranty: Full replacement or return within 18 months if non-conforming to published specs (backed by ISO 9001:2015).
Customer Support: 24/7 technical hotline, batch-COA downloads, live tracking, and on-site auditing by client request.

EEAT in Action: Industry Validation, Trusted Partnerships

Sincere Chemicals: ISO 9001:2015, REACH & RoHS certificates; annual capacity: 8,000MT.
Primary partnerships: Samsung SDI, BASF, Merck, Sinopec.
2023 customer satisfaction: 98.7% (Supplier Survey, Chemweek China).
Quoted in ACS Omega for battery electrolyte R&D: “TMEDA advanced grades enhanced electrolyte conductivity by 35% in LFP cells.”

Application Scenarios & Success Cases

Batteries & Energy Storage: TMEDA is vital in formulating lithium-ion battery electrolytes, where it stabilizes Li-ion carriers and extends cell life (test cycle: 2,500 cycles at 80% DOD).
Polymer & Resin Manufacturing: Used as an accelerator for radical polymerization (e.g., PMMA, polyol), reducing catalyst consumption by up to 28%.
Pharmaceutical Synthesis: TMEDA enables regioselective amination in API production—improving yield and purity, supported by FDA cGMP standards.
Water Treatment & Metallurgy: Forms complexes with heavy metal ions (Cu, Ni, Zn), improving flocculation/precipitation in wastewater with high selectivity.
R&D Custom Projects: Custom-purified TMEDA supplied for semiconductors and OLED research through university-industry alliances (ref: Nanoscale Res., 2021).

Case Highlight: In 2023, a Sinopec subsidiary adopted Sincere Chemicals’ battery-grade Tetramethylethylenediamine, resulting in a 20% improvement in Li-ion battery consistency and 15% lower annualized maintenance overhead (internal tech report, 2024).

Expert FAQ: Tetramethylethylenediamine Technical Dossier

Frequently Asked Technical Questions

1. What is the core material composition of Tetramethylethylenediamine?

TMEDA is a symmetric diamine (C₆H₁₆N₂), synthesized from dimethylamine and ethylene oxide, forming a non-aromatic, amphiphilic structure highly effective as a chelating agent in coordination chemistry.

2. Which purity grades are typical for industrial and battery-grade TMEDA?

Industrial grade is usually ≥99.0%, battery/electronic grade can reach 99.9% (trace sodium,

3. Which international standards and approvals apply to TMEDA?

ISO 9001:2015, REACH and RoHS compliance are global benchmarks. For pharma, cGMP and FDA standards (21 CFR Part 210/211). Select clients may request UL, CE or ANSI/SAE packaging/test docs.

4. What storage and handling precautions are necessary?

Store in sealed, inert-atmosphere container111s (HDPE or stainless steel), away from acids/oxidizers, at 2–25°C. ANSI Class II safety gear, VOC extraction, and sensor-monitored drum rooms are standard practice.

5. What is the standard delivery period and logistics mode?

Typical EXW/FOB delivery: 7-14 days post order confirmation. Bulk or tank shipments use UN-certified routes, with optional on-site technical inspection. Emergency delivery: 72 hours on contract.

6. Can TMEDA be used for food or medical devices?

No; while high-purity TMEDA is available, it is not FDA-approved as a food additive or for direct medical device manufacturing. For APIs/pharma, only cGMP grades with accompanied DMF are permissible.

7. What after-sales and technical support services are available?

Sincere Chemicals offers multilingual technical support, on-demand COA/SDS provision, remote/on-site troubleshooting, and free technical seminars for supply contract customers.