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Pharmaceutical applications further underscore the expertise required in using PMDTA. In drug synthesis, it is employed as a ligand in organometallic reactions, which are pivotal in forming carbon-carbon and carbon-heteroatom bonds. The ability of PMDTA to enhance reaction rates and yields makes it an invaluable tool in drug discovery and development. Its incorporation into complex synthetic routes necessitates a high level of understanding and expertise to maximize efficiency and safety, ensuring the reliability of the end pharmaceutical product.