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The application spectrum of TMEDA is extensive. In the realm of organometallic chemistry, TMEDA's role as a ligand is pivotal. It acts to augment the solubility and reactivity of metal complexes, allowing for more efficient and controllable reactions. Its inclusion in reactions involving Grignard reagents and lithium amides, for instance, significantly boosts the yields and selectivity of target compounds. Additionally, TMEDA is known to play a vital part in facilitating the stereoselective synthesis of complex molecules, which are central to pharmaceuticals and agrochemicals.
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