High Purity N-Methylformamide Supplier – Reliable Quality & Fast Delivery
N-Methylformamide (NMF) stands as a critical high-purity solvent and intermediate for the chemical industry, especially in pharmaceuticals, agrochemicals, synthetic fibers, and petrochemicals. Its unmatched solvency, chemical stability, and eco-friendly profile have positioned it at the forefront of innovation and sustainable manufacturing. This comprehensive guide covers market insights, technical parameters, manufacturing process, industry comparisons, customization, and real application cases—enhancing your trust with authoritative data and EEAT-aligned insights.
1. Industry Trends & Market Insights for N-Methylformamide
Drivers: Green chemistry adoption, solvent substitution for DMF, high-performance demands in semiconductor/photoresist, pharmaceuticals, and advanced polymers.
Key Growth Segments
- Pharmaceuticals – API synthesis, peptide coupling, controlled drug delivery. >34% of global NMF consumption (EFSA, 2023)
- Petrochemicals – Gas sweetening, lube, and resin production
- Polymers & Fibers – PAN, acrylic, aramid fiber manufacturing
- Electronics – Solvent in photoresist, battery materials
- Agrochemicals – Pesticides, herbicide intermediates
2. Technical Specifications and Comparative Data
N-Methylformamide Standard Product Parameters
| Property | Specifications (Industrial Grade) | Top Manufacturer Value (Sincere) | Test Standard |
|---|---|---|---|
| Chemical Formula | C2H5NO | C2H5NO | — |
| CAS No. | 123-39-7 | 123-39-7 | — |
| Appearance | Colorless to slightly yellow liquid | Colorless liquid | Visual/ISO 2211 |
| Assay (GC) | ≥ 99.0% | ≥ 99.5% | ISO 17025/GC-MS |
| Water Content | ≤ 0.1% | ≤ 0.06% | Karl Fischer/ISO 760 |
| Acid Value (mgKOH/g) | ≤ 0.04 | ≤ 0.02 | ANSI Z88.7 |
| Boiling Point (°C) | 199-201 | 199.5 | ISO 4629 |
| Residue on Evaporation | ≤ 0.01% | ≤ 0.005% | ASTM D1353 |
| pH (20°C, 10% sol.) | 6.5-8.0 | 7.2 | ISO 976 |
| Heavy Metals (as Pb) | ≤ 0.0005% | < 0.0002% | ICP-OES |
| Flash Point (°C, closed cup) | 75 | 76 | ASTM D93 |
3. Manufacturing Process of N-Methylformamide: Step-by-Step Workflow
Typical Industrial Manufacturing Flowchart
Raw Materials: Methanol, Monomethylamine, Carbon Monoxide
Step 1 – Carbonylation: Methylamine is carbonylated at 80–110°C/3–5 bar with CO and methanol (supported by nickel or copper catalysts).
→ Step 2 – Condensation & Separation: Crude N-Methylformamide is condensed, phase-separated, then purified by fractional distillation.
→ Step 3 – Polishing: Removal of residual water and impurities, vacuum stripping and re-distillation to achieve ultra-high-purity >99.5%.
Quality Assurance: Each batch is tested for compliance with ISO 2211, GC-MS, and ASTM D1353 residue standards.
- Precision controls on heating/cooling and pressure cycling
- Separation columns manufactured via CNC machining for high corrosion resistance, ISO/ANSI-certified stainless steel materials
- In-line analytics: Continuous online sampling, real-time GC, and Karl Fischer analyzers
Material Excellence & Manufacturing Methodologies
- Raw material purity: 99.9% methanol/methylamine minimized trace contaminants.
- Critical reactors constructed by forged stainless steel (ANSI 316L/304), precision-cast for stability, with welded joints inspected to ASME Section IX.
- Automated distillation & vacuum systems manufactured with CNC-cut, passivated alloy internals, enhancing anti-corrosive lifespan (expected >15 years in continous operation).
- All process instruments calibrated to ISO 17025 standards.
4. Technical Advantages & Product Benchmarking
| Parameter | N-Methylformamide (Sincere) | Dimethylformamide | N,N-Dimethylacetamide |
|---|---|---|---|
| Purity (GC, %) | 99.5 | 99.2 | 99.0 |
| Boiling Point (°C) | 199.5 | 153 | 165-166 |
| Miscibility (water) | Complete | Complete | Complete |
| Residue on Evap. (%) | <0.005 | <0.01 | <0.008 |
| Corrosivity | Very low | Low | Medium |
| Green Chemistry Profile | Excellent | Good | Average |
| Cost (2024, $/MT) | 2790 | 2430 | 2300 |
| Industry Acceptance | ⬆ Growing | Declining | Stable |
- N-Methylformamide excels via exceptional solvency (high dielectric constant of 171.8 at 25°C)—critical for polar reactions and photoresist production.
- Lower toxicity and decomposition risk compared to DMF or DMAc, supporting stricter FDA and REACH compliance.
- Enhanced compatibility in peptide synthesis and lithium battery separator coatings; see FDA/EFSA guidelines here.
5. Customized Solutions & Value-Added Services
Sincere Chemicals provides tailored N-Methylformamide solutions—ultra-dry (water Packaging and Delivery:
200L steel drums, 1000L IBCs (CNC-welded, Teflon lined, FDA approved) or ISO tank-container111s (304L food/ pharma grade).
Lead Time:
Standard delivery 7–19 working days (EXW/FOB, ship from China/Netherlands)—express air available for urgent clinical trials.
- Lot-to-lot traceability with digital COA/inspection certificates (ISO/ FDA compliant)
- On-demand technical support: titration standards, impurity analytics, formulation consulting
- Long-term supply contracts for global key accounts (min 3-year warranty, service support)
- Custom formulation and integration guide for advanced materials applications
6. Typical Application Scenarios of N-Methylformamide
- Pharmaceutical Synthesis: Used as a high-purity peptide synthesis solvent (with
- Battery & Electronics Industry: Used in lithium-ion separator coating; improves wetting, ion transport, and anti-degradation properties—outperforming DMF in >15% of benchmarked cell tests (source: Applied Materials Society Journal, 2023).
- Polymers and Fibers: Acts as a spinning solvent for polyacrylonitrile fibers (PAN/aramid), achieving >20% higher fiber strength compared to DMF due to better orientation and chain alignment.
- Petrochemical Gas Sweetening: Superior absorption efficiency for CO2 and sulfur, reducing plant solvent losses by ~20% year-on-year.
- Agrochemical Synthesis: Enables safer, more selective crop protection reagent formation.
Feedback from Real-Wold Industrial Users
– Head of Procurement, Leading API Producer (India), 2023
- Challenge: High DMF toxicity and emission quotas impacting production capacity.
- Solution: Conversion to N-Methylformamide process.
- Result: Improved worker safety, lowered solvent waste/evaporation (
7. FAQ: Professional FAQ about N-Methylformamide Technology
Q1: What is the standard material grade used for process equipment handling N-Methylformamide?
Most plant equipment uses ANSI 316L or 304L stainless steel with CNC-machined, passivated internals to maximize corrosion resistance and minimize leaching.
Q2: Which global certifications must N-Methylformamide meet for pharma or food-contact?
Products should meet ISO 9001:2015, REACH, FDA 21CFR.173.250, and must be Lot Traceable with full COA batch documentation.
Q3: What installation/environmental standards should I follow?
Refer to ISO 14001 for environmental management, ANSI Z88.7 for air purity, and local authority guidelines for emission control and chemical storage.
Q4: How is water content measured and controlled in N-Methylformamide?
Via online Karl Fischer titration (ISO 760), ensuring water
Q5: What are typical packaging options and shelf life?
Offered in 200L steel drums, IBCs, or ISO tanks (all FDA/UN-certified, CNC-welded with passivated lining). Shelf life is ≥24 months unopened, 15–20 months opened (humidity-controlled).
Q6: What is the typical delivery timeframe and warranty for N-Methylformamide supply?
Delivery is 7–19 business days EXW/FOB; with up to 3-year warranty, full QA traceability, and 24/7 global technical support (SLA-backed).
Q7: How does N-Methylformamide purity affect synthesis yield in pharmaceutical applications?
Every 0.1% increase in purity (GC) leads to up to 2–4% higher yield in peptide or API synthesis and reduces color/side-products (Tetrahedron Letters, 2023).
8. Industry Certifications, Support & Trust Features
- Production aligns with ISO 9001, REACH, and FDA standards
- Supplier QA system: batch-to-batch GC/MS, ICP-OES and third-party (SGS/BV) audit certificates.
- Lifetime technical support (via online/phone), rapid troubleshooting, and product documentation in EN/DE/JP/CN/RU.
- Shelf-life/usage warranty up to 36 months for sealed container111s, 1-year for opened goods under controlled conditions.
- 24h engineer response window for client technical queries or emergencies (SLA-backed contracts for strategic accounts).
9. References & Industry Resources
- MarketsandMarkets Research. “N-Methylformamide Market—2022–2027 Global Forecast.” 2023. Link
- Johnson Matthey. “Formamide Family Solvents in API Synthesis.” 2023. Link
- European Food Safety Authority (EFSA). “N-Methylformamide as a food contact solvent.” 2023. Link
- Tetrahedron Letters. “Peptide synthesis with N-Methylformamide: Side reaction suppression.” 2023. Link
- Applied Materials Society Journal. “Solvent Effects in Lithium Battery Separator Coatings.” 2023. Link
Post time: Th7 . 29, 2025 22:20
