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In recent years, the importance of 2,2’-Dichlrodiethylether (commonly referred to as 2 and known by its CAS No. 111-45-5) has significantly risen in chemical synthesis, pharmaceuticals, and advanced manufacturing. This article delivers a holistic technical and industrial perspective on 2,2’-Dichlrodiethylether,
navigating through its manufacturing process, technical benchmarks, industry data, vendor analysis, customization, and use-case scenarios.
For product details, visit the official: 2,2’-Dichlrodiethylether.

1. Industry Trends and Market Demand
- Global Market Growth: According to MarketsandMarkets, the ether market—including 2-compounds—is projected to reach USD 9.6 billion by 2027, fueled by the rapid expansion of chemical intermediates and specialty solvents.
- Downstream Applications: Significant growth noted in pharmaceuticals (21% CAGR), agrochemicals, metal extraction, and specialty coatings, with 2,2’-Dichlrodiethylether showcasing prominent solvent and intermediate functions.
- Regional Distribution: Asia-Pacific (esp. China, India) leads demand, accounting for 48% of consumption due to high-volume fine chemical manufacturing.
2. Technical Parameters & Product Specification
Parameter | Specification | Industry Standard |
---|---|---|
Chemical Name | 2,2’-Dichlrodiethylether | CAS 111-45-5 |
Molecular Formula | C4H8Cl2O | – |
Molecular Weight | 143.01 g/mol | – |
Appearance | Colorless or pale yellow liquid | ISO 6271 |
Purity | ≥99.5% | ISO 9001:2015, ANSI Z540 |
Boiling Point | 163–164°C | ASTM E537 |
Flash Point | 57°C (Closed Cup) | NFPA 704 |
Water Solubility | <0.01 g/100 mL at 20°C | ISO 22241 |
Density | 1.18–1.20 g/cm3 at 20°C | ASTM D4052 |
Refractive Index | 1.436–1.438 | ISO 5661 |
- Specialty solvent for intermediates in chemical synthesis
- Agrochemical processing for herbicide/pesticide synthesis
- Pharmaceutical sector: extraction of bioactive alkaloids
- Metallurgical: catalyst or phase-transfer reagent
- Water treatment: industrial scale-organic phase operations
3. Manufacturing Process Flow & Quality Control
Sourced under ISO 9001-certified suppliers.
Catalyzed using KOH or NaOH; monitored for temperature/pressure.
Controlled at 90–110°C in inert gas; continuous stirring (ANSI levels).
Distillation and molecular sieving; multi-stage quality checks (ISO 17025).
GC-MS for purity; sealed in corrosion-resistant drums (per ASTM D3951).

- Core Material: High-purity industrial-grade 2 is synthesized from epichlorohydrin and chlorinated ethanol derivatives via controlled catalytic processes.
- Manufacturing Technology: Precision batch reactors, continuous-flow distillation, CNC-programmed filling/sealing operations.
- Detection Technology: GC-MS, IR spectroscopy, and HPLC for quality control (ISO/IEC 17025 accreditationCertified).
- Standards Compliance: Meets/Exceeds ISO 9001:2015, ANSI Z540, and selected lots tested against REACH/SGS environmental directives.
- Service Life: In sealed, inert storage, >2 years with <0.1% observed impurity degradation (industry field test, 2023, Source: ACS)
- Industries Served: Petrochemical, Mining & Metallurgy, Advanced Water Treatment, Fine Chemical Intermediates, and Industrial Pharmaceuticals.
4. Data Visualization: Technical Benchmarking
5. Vendor Comparison & Customization Capabilities
Supplier | Annual Output (MT) | Certifications | Purity | Lead Time | Customization |
---|---|---|---|---|---|
Sincere Chemicals | 1,500 | ISO 9001, SGS, REACH | ≥99.5% | 5-12 days | Volume, Packaging, Purity |
Sigma-Aldrich | 350 | GMP, ISO 9001 | ≥99.0% | In Stock | Packing, Analytical Spec |
Alfa Aesar | 120 | ISO 9001 | ≥98.5% | 8-16 days | Lab Pack, Bulk |
- Custom purity grades (from 98% up to 99.9%) for advanced R&D or high-performance manufacturing
- Packaging: 5L HDPE bottles to 200L lined drums, UN-certified container111s for export
- Labeling in line with international standards (GHS, CLP), multilingual MSDS included
- Technical support: process audit, usage optimization consulting, COA/COQ provided
- OEM solutions with barcoded shipment tracking and end-to-end QA traceability
6. Application Scenarios & Technical Advantages
- Solvent in API (active pharmaceutical ingredient) intermediate synthesis — pharma sector relies on high-purity 2,2’-Dichlrodiethylether for clean reaction profiles.
- Pesticide and herbicide manufacturing — used as a selective chlorinated ether solvent, known for its inertness in high-pH environments.
- Extraction and purification of alkaloids — excellent partition coefficients for organic/aqueous separations.
- Catalytic agent in precious metal recycling — effective under both batch and continuous flow regimes.
- Industrial coatings — imparts improved film-forming and anti-corrosive properties.
- Advanced water treatment — co-solvent in producing permeable membranes or resins for municipal/industrial use.
Customer: Major EU pharmaceutical (2022)
Challenge: Poor impurity removal in final API crystallization using conventional solvents.
Solution: Substituted with Sincere Chemicals’ 2,2’-Dichlrodiethylether, 99.5%.
Result: Assay purity improved +2.6%, with a 16% reduction in downstream washing steps.
Feedback: "The use of dichlrodiethylether drastically reduced solvent rework and increased API throughput."

- Energy efficiency: Reduced heat load in high-boiling reactions (up to 19% less gas consumption, 2022 Sincere pilot data).
- Corrosion resistance: Suited for continuous processing equipment, mitigating corrosion risks compared to lower-boiling ethers.
- Superior selectivity: Narrow boiling window enables stringent process control.
- Compatibility: Works with steel, glass-lined, and select polymer vessels per ISO 11114-2.
7. Service Commitments & Customer Support
- Delivery Cycle: Standard in-stock volumes shipped within 5-12 business days worldwide; expedited handling on project basis.
- Warranty: Up to 24 months shelf life under specified storage; batch-level warranty documentation provided.
- Customer Support: Multilingual technical support, on-site troubleshooting (ISO 10002 certified), 24/7 customer portal access.
- Authenticity: Each batch accompanied with COA (Certificate of Analysis) & COQ (Certificate of Quality).
- Sustainability: Compliant with REACH, RoHS, and ISO 14001 environmental standards. Triple-locked packaging eliminates cross-contamination risk.
8. Frequently Asked Technical Questions (FAQ)
A: The core composition is C4H8Cl2O, manufactured from chloroethanol under controlled, catalytic dehydrohalogenation.
A: It is packed in HDPE or internally lined drums, UN-certified per DOT/ADR, and routinely tested per ASTM D3951 for integrity and leakage.
A: Gas chromatography-mass spectrometry (GC-MS), further supported by IR and NMR spectroscopy (ISO/IEC 17025 lab-accreditation).
A: Facilities must comply with ISO 14001, ANSI/SIA Z358, and GHS/OSHA hazard communication for safe handling and storage.
A: Yes, when sourced with a supporting DMF (Drug Master File), COA, GMP-compliance traceability and validated analytical specs.
A: It minimizes the need for reflux condensers and shortens batch times due to its suitable mid-range boiling point and narrow temperature operation window.
A: Standard: 5–12 days; expedited requests accommodated on a priority basis with full logistics support and real-time tracking.
9. Authoritativeness, Industry Citations & Acknowledgments
- Manufacturing and export facilitated by Sincere Chemicals — 16+ years in advanced ether technology, serving Fortune 500 chemical and pharmaceutical clients.
- Products tested in ISO/IEC 17025-certified labs, with third-party verification (SGS, Intertek).
- Industry recognition: supplier for global pharma, mining, and water treatment projects.
- Compliance with international chemical regulations: REACH, GHS, CLP, RoHS.
- Customer satisfaction (2023 survey): 96.4% rate post-sales technical support as “Excellent”.
- Selected as preferred vendor on ChemicalBook, PubChem.
Post time: Авг . 04, 2025 12:20
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