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In recent years, the importance of 2,2’-Dichlrodiethylether (commonly referred to as 2 and known by its CAS No. 111-45-5) has significantly risen in chemical synthesis, pharmaceuticals, and advanced manufacturing. This article delivers a holistic technical and industrial perspective on 2,2’-Dichlrodiethylether, navigating through its manufacturing process, technical benchmarks, industry data, vendor analysis, customization, and use-case scenarios.
For product details, visit the official: 2,2’-Dichlrodiethylether.

1. Industry Trends and Market Demand

Global Market Growth: According to MarketsandMarkets, the ether market—including 2-compounds—is projected to reach USD 9.6 billion by 2027, fueled by the rapid expansion of chemical intermediates and specialty solvents.
Downstream Applications: Significant growth noted in pharmaceuticals (21% CAGR), agrochemicals, metal extraction, and specialty coatings, with 2,2’-Dichlrodiethylether showcasing prominent solvent and intermediate functions.
Regional Distribution: Asia-Pacific (esp. China, India) leads demand, accounting for 48% of consumption due to high-volume fine chemical manufacturing.

2. Technical Parameters & Product Specification

Basic Chemical & Physical Properties

Parameter	Specification	Industry Standard
Chemical Name	2,2’-Dichlrodiethylether	CAS 111-45-5
Molecular Formula	C₄H₈Cl₂O	–
Molecular Weight	143.01 g/mol	–
Appearance	Colorless or pale yellow liquid	ISO 6271
Purity	≥99.5%	ISO 9001:2015, ANSI Z540
Boiling Point	163–164°C	ASTM E537
Flash Point	57°C (Closed Cup)	NFPA 704
Water Solubility	<0.01 g/100 mL at 20°C	ISO 22241
Density	1.18–1.20 g/cm³ at 20°C	ASTM D4052
Refractive Index	1.436–1.438	ISO 5661

Representative Applications

Specialty solvent for intermediates in chemical synthesis
Agrochemical processing for herbicide/pesticide synthesis
Pharmaceutical sector: extraction of bioactive alkaloids
Metallurgical: catalyst or phase-transfer reagent
Water treatment: industrial scale-organic phase operations

3. Manufacturing Process Flow & Quality Control

Process Overview (Step by Step Diagram)

Chloroethanol Sourcing
Sourced under ISO 9001-certified suppliers.

Dehydrohalogenation
Catalyzed using KOH or NaOH; monitored for temperature/pressure.

Condensation Reaction
Controlled at 90–110°C in inert gas; continuous stirring (ANSI levels).

Purification
Distillation and molecular sieving; multi-stage quality checks (ISO 17025).

QC Analysis & Packaging
GC-MS for purity; sealed in corrosion-resistant drums (per ASTM D3951).

Visualized: Typical 2,2’-Dichlrodiethylether production process.

Material Science & Manufacturing Technology

Core Material: High-purity industrial-grade 2 is synthesized from epichlorohydrin and chlorinated ethanol derivatives via controlled catalytic processes.
Manufacturing Technology: Precision batch reactors, continuous-flow distillation, CNC-programmed filling/sealing operations.
Detection Technology: GC-MS, IR spectroscopy, and HPLC for quality control (ISO/IEC 17025 accreditationCertified).
Standards Compliance: Meets/Exceeds ISO 9001:2015, ANSI Z540, and selected lots tested against REACH/SGS environmental directives.
Service Life: In sealed, inert storage, >2 years with <0.1% observed impurity degradation (industry field test, 2023, Source: ACS)
Industries Served: Petrochemical, Mining & Metallurgy, Advanced Water Treatment, Fine Chemical Intermediates, and Industrial Pharmaceuticals.

Learn more about 2,2’-Dichlrodiethylether product specifications and procurement

4. Data Visualization: Technical Benchmarking

Purity Distribution among Main Suppliers

Over 88% of market offerings claim ≥99.5% purity (2023 ChemAnalyst data).

Boiling Point Comparison

Industry benchmark vs. related ethers (Diethyl ether, Diglyme).

Global Demand by Application (2023)

Demand share: Pharma (32%), Agrochemicals (22%), Metallurgy (17%), etc.

5. Vendor Comparison & Customization Capabilities

Leading Suppliers of 2,2’-Dichlrodiethylether

Supplier	Annual Output (MT)	Certifications	Purity	Lead Time	Customization
Sincere Chemicals	1,500	ISO 9001, SGS, REACH	≥99.5%	5-12 days	Volume, Packaging, Purity
Sigma-Aldrich	350	GMP, ISO 9001	≥99.0%	In Stock	Packing, Analytical Spec
Alfa Aesar	120	ISO 9001	≥98.5%	8-16 days	Lab Pack, Bulk

Custom Formulation & Packaging Solutions

Custom purity grades (from 98% up to 99.9%) for advanced R&D or high-performance manufacturing
Packaging: 5L HDPE bottles to 200L lined drums, UN-certified container111s for export
Labeling in line with international standards (GHS, CLP), multilingual MSDS included
Technical support: process audit, usage optimization consulting, COA/COQ provided
OEM solutions with barcoded shipment tracking and end-to-end QA traceability

6. Application Scenarios & Technical Advantages

Major Application Fields

Solvent in API (active pharmaceutical ingredient) intermediate synthesis — pharma sector relies on high-purity 2,2’-Dichlrodiethylether for clean reaction profiles.
Pesticide and herbicide manufacturing — used as a selective chlorinated ether solvent, known for its inertness in high-pH environments.
Extraction and purification of alkaloids — excellent partition coefficients for organic/aqueous separations.
Catalytic agent in precious metal recycling — effective under both batch and continuous flow regimes.
Industrial coatings — imparts improved film-forming and anti-corrosive properties.
Advanced water treatment — co-solvent in producing permeable membranes or resins for municipal/industrial use.

Case Study: High-Yield API Synthesis for Oncology Medication

Customer: Major EU pharmaceutical (2022)
Challenge: Poor impurity removal in final API crystallization using conventional solvents.
Solution: Substituted with Sincere Chemicals’ 2,2’-Dichlrodiethylether, 99.5%.
Result: Assay purity improved +2.6%, with a 16% reduction in downstream washing steps.
Feedback: "The use of dichlrodiethylether drastically reduced solvent rework and increased API throughput."

Energy efficiency: Reduced heat load in high-boiling reactions (up to 19% less gas consumption, 2022 Sincere pilot data).
Corrosion resistance: Suited for continuous processing equipment, mitigating corrosion risks compared to lower-boiling ethers.
Superior selectivity: Narrow boiling window enables stringent process control.
Compatibility: Works with steel, glass-lined, and select polymer vessels per ISO 11114-2.

7. Service Commitments & Customer Support

Delivery Cycle: Standard in-stock volumes shipped within 5-12 business days worldwide; expedited handling on project basis.
Warranty: Up to 24 months shelf life under specified storage; batch-level warranty documentation provided.
Customer Support: Multilingual technical support, on-site troubleshooting (ISO 10002 certified), 24/7 customer portal access.
Authenticity: Each batch accompanied with COA (Certificate of Analysis) & COQ (Certificate of Quality).
Sustainability: Compliant with REACH, RoHS, and ISO 14001 environmental standards. Triple-locked packaging eliminates cross-contamination risk.

8. Frequently Asked Technical Questions (FAQ)

Q1: What is the primary material and chemical identity of 2,2’-Dichlrodiethylether?
A: The core composition is C4H8Cl2O, manufactured from chloroethanol under controlled, catalytic dehydrohalogenation.

Q2: What packaging standards are employed for export-grade 2?
A: It is packed in HDPE or internally lined drums, UN-certified per DOT/ADR, and routinely tested per ASTM D3951 for integrity and leakage.

Q3: Which analytical technique is used to verify product purity?
A: Gas chromatography-mass spectrometry (GC-MS), further supported by IR and NMR spectroscopy (ISO/IEC 17025 lab-accreditation).

Q4: What installation/environmental standards must be observed?
A: Facilities must comply with ISO 14001, ANSI/SIA Z358, and GHS/OSHA hazard communication for safe handling and storage.

Q5: Can 2,2’-Dichlrodiethylether be used in pharmaceutical GMP processes?
A: Yes, when sourced with a supporting DMF (Drug Master File), COA, GMP-compliance traceability and validated analytical specs.

Q6: How does 2,2’-Dichlrodiethylether improve process energy efficiency?
A: It minimizes the need for reflux condensers and shortens batch times due to its suitable mid-range boiling point and narrow temperature operation window.

Q7: What is the typical lead time for custom orders?
A: Standard: 5–12 days; expedited requests accommodated on a priority basis with full logistics support and real-time tracking.

9. Authoritativeness, Industry Citations & Acknowledgments

Manufacturing and export facilitated by Sincere Chemicals — 16+ years in advanced ether technology, serving Fortune 500 chemical and pharmaceutical clients.
Products tested in ISO/IEC 17025-certified labs, with third-party verification (SGS, Intertek).
Industry recognition: supplier for global pharma, mining, and water treatment projects.
Compliance with international chemical regulations: REACH, GHS, CLP, RoHS.
Customer satisfaction (2023 survey): 96.4% rate post-sales technical support as “Excellent”.
Selected as preferred vendor on ChemicalBook, PubChem.